Nuritas and its Nuritas MagnifierNπΦ platform offers the potential to unlock plant-based, efficacious solutions to a myriad of health problems, with a reported success rate of up to 1,200 times that of traditional R&D, in 80% less time.
In the food and nutrition space, the company offers PeptiStrong (with muscle building, anti-muscle atrophy and anti-inflammation properties), while they also worked with BASF to develop PeptAIde for modulation of inflammation with respect to exercise.
For the cosmetics and personal care space, the company used its AI technology to identify and develop PeptiYouth, from pea (Pisum sativum).
“PeptiYouth is unique: It has been hidden in plain sight in nature for 100 million years, but, until today, we lacked the precision technology to discover it,” said Marie Bruckert, Nuritas Growth Marketing and Business Strategy Director. “This intelligent ingredient is the first AI-discovered nature-identical peptide that delivers superior clinically-proven anti-aging efficacy.”
Five key signs of aging that PeptiYouth targets include lines and deep wrinkles, dull skin, pores, dark spots and uneven skin tone. Because it can be used at a low dose of 35ppm, the peptide can be added to existing formulas. The peptide has shown success in a variety of topical products including serums, pigmented makeup, eye creams, face creams and SPF. Each of these formulations by Nuritas also include other beneficial ingredients such as hyaluronic acid and retinol.
The two clinical trials included both males and females between 45 and 85 years old who showed visible signs of aging. In both clinical trials, the product was tested against a placebo. Testing included cross-polarized light, which is used to diagnose skin cancers. Benefits were demonstrated on both a short- and long-term front, from 14 to 56 days.
Cellularly, PeptiYouth helps to increase the number of receptors for retinol binding protein on cell membranes. This can yield results within 14 days. Bruckert says it is unlikely the peptide would have been discovered if not for AI. “In this industry, AI makes it feasible for us to unlock previously-untapped “intelligent” ingredients from nature, allowing us to break the decades-old cycle of poor quality products.
“In a universe that can contain 6 trillion peptides, our AI technology can quickly narrow down this search to a handful of candidates, including the feasibility criteria that are adapted to the cosmetics and personal care industry.” Another examples includes PeptiStrong, a sports nutrition ingredient that helps to synthesize new muscle. According to Bruckert, their technology helps search specifically for peptides that will serve consumer needs.
Bruckert said one of the main challenges they faced with PeptiYouth included “how to launch a peptide that is nature-identical, not chemically modified.” Since solving any challenges they faced to market entry, she said, “PeptiYouth has the potential to replace several ingredients in a formula and to build shorter, cleaner formulas, while delivering superior benefits.”
In the next five years, Nuritas hopes to have 24 ingredients like PeptiYouth that will address a range of areas of health and wellbeing.
Source: International Journal of Cosmetic Science
2020, Volume 42, Issue 4, Pages 388-398, doi: 10.1111/ics.12635
"The anti-ageing effects of a natural peptide discovered by artificial intelligence"
Authors: K. Kennedy, et al.