P&G study shows more tolerance to PPD derivative hair dye and stresses pretest importance

By Andrew MCDOUGALL contact

- Last updated on GMT

P&G study shows more tolerance to PPD derivative hair dye and stresses pretest importance

Related tags: Hair dye, Hair color, Hairstyle, Hair coloring

A new study carried out by Procter & Gamble with University Trier and the University of Groningen has found that individuals who are allergic to para-phenylenediamine (PPD) in hair dyes, better tolerate one of the manufacturer’s own derivatives; although this is not without reactions, with the study stressing the importance of pretesting.

The less sensitizing PPD derivative 2-methoxymethyl (ME-PPD) is currently used in commercial products marketed by P&G, and was shown to be more tolerated by individuals with a history of allergic reactions, according to the study published in the British Journal of Dermatology​.

In the study, the research team found that hair dye products with ME-PPD were tolerated by 29 out of 43 (67%) allergic individuals throughout continued hair dyeing with an average of nine treatments per year.

Five individuals reacted upon pretesting, while only mild-to-moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest.

“To our knowledge this is the first study among PPD/PTD-allergic individuals indicating that a negative 45-min pretest with a hair dye product helps to avoid severe allergic reactions,”​ says the study.

Tests

In the study, elicitation reactions were studied in 43 PPD and/or toluene-2,5-diamine (PTD)-allergic individuals by a 45 minute pretest with an ME-PPD-containing hair dye on their forearm.

Upon a negative result this was followed by exposure to subsequent hair colour treatments.

Overall, 38 of the 43 PPD/PTD-allergic individuals did not develop an elicitation reaction during the pretest with ME-PPD-containing hair dye products, and were eligible for subsequent hair colour treatments.

Of these 38 PPD/PTD-allergic individuals, 29 tolerated subsequent hair dyeing with ME-PPD-containing hair dye products, while seven showed mild and two showed moderate/marked allergic reactions upon the first hair colour treatment.

Caution urged

The scientists say they decided to investigate the elicitation reactions of ME-PPD in previously allergic individuals because despite a positive patch test reaction to PPD and/or PTD, many people still attempt to continue dyeing their hair with products containing PPD or its derivatives.

The team still mention warnings not to use ME-PPD hair colorants in case of hair dye allergy, and that the results indicate that hair dyeing with ME-PPD-containing hair colour is associated with a certain risk for PPD/PTD-allergic hair dye consumers, with a (cross-)elicitation rate of approximately 30%.

“Based on this experience with the small number of 43 allergic individuals, pretesting with the hair colour product of choice can be considered helpful to provide an alert of a strong (cross-)reactivity, but it is insufficient to provide an indication of the absence of mild to moderate/marked symptoms,” ​it concludes.

Related topics: Formulation & Science, Hair Care

Related products

show more

Multi-Cultural Vegan Keratin Protein!

Multi-Cultural Vegan Keratin Protein!

TRI-K Industries Inc. | 02-Mar-2020 | Data Sheet

TRI-K’s new multi-cultural animal free protein, KeraPlant NPNF®, has a broad amino acid range for optimized damage recovery. This vegan keratin aids in...

Amino acid based, eco-friendly preservative

Amino acid based, eco-friendly preservative

TRI-K Industries Inc. | 03-Feb-2020 | Data Sheet

TRI-K Industries, Inc., has launched a new eco-friendly preservative! Galguard Trident S uses an environmentally friendly, award winning smart catalysis...

Beauty Tech Unboxed: innovation for the digital age

Beauty Tech Unboxed: innovation for the digital age

Sagentia Limited | 13-Jan-2020 | Research Study

Sagentia recently conducted quantitative and qualitative research with more than 2,000 UK adults. Our aim was to drill down into the basics of what digital...

SABERRY®: MULTIFACETED AND MULTITASKING

SABERRY®: MULTIFACETED AND MULTITASKING

SABINSA: Innovating the Science of Cosmetics® | 01-Nov-2019 | Technical / White Paper

Beta-glucogallin is the potent anti-aging molecule in Saberry® responsible for preventing oxidative stress and degradation of skin proteins. This patented...

Related suppliers

Follow us

Products

View more

Webinars