Provital’s nutmeg-derived active offers non-invasive plumping of wrinkles

Noline is a polyphenol from nutmeg seeds called macelignan, and is designed for use in a variety of anti-ageing products.

The ingredient works on the adipose tissue, which the company says plays an important role in aging. As we age lipids redistribute, which leads to changes in facial appearance with a decrease in skin volume and the appearance of lines and wrinkles, according to the company.

Targeting adipose tissue​

Adipose tissue contains both pre-adipocytes and adipocytes (storing lipids). When pre-adipocytes transform into adipocytes (adipogenesis), the result is smoother skin, according to the company.

As the skin ages, adipogenesis and lipid storage diminishes, which manifests itself in the visible signs of ageing.

Provital says that Noline stimulates the key receptor in adipogenesis – PPAR-y – which increases the number of adipocytes in the adipose tissue and the amount of lipids stored in them, ultimately filling wrinkles.

In-vivo ​tests ​

In-vivo tests ​carried out on the ingredient showed it to have an effect on the appearance of wrinkles, with 76 per cent of volunteers reporting a positive response.

The study was conducted amongst 25 volunteers between the ages of 35 and 50 over a period of 28 days.

The formulation with macelignan at 0.25 per cent was applied to the eye contour, and effects were measured against a placebo on the same volunteer.

The results showed a reduction in wrinkles of up to 19 per cent, and an improvement of up to 25 per cent in average roughness of the skin, according to the company.

Among the anti-ageing applications for which Noline is suitable are anti-ageing specific serums and hand treatments, according to the company, who also said the ingredient can be used as a complement to facial firming products.