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Hair loss development as pathway found that can prompt or limit growth

By Andrew McDougall+

18-Dec-2013

The hair loss world has witnessed a new development after scientists identified a molecular pathway that can be activated to prompt hair growth of dormant hair follicles, or blocked to prevent growth of unwanted hair.

The study, published in Cell Stem Cell, was carried out by researchers with the Perelman School of Medicine at the University of Pennsylvania, and focuses on Wnt signalling which has often gone under the microscope in hair growth.

Contrary to previous studies, this research states that the pathway, known for its role in regulating adult stem cells and has been shown to be important for hair follicle proliferation, is not required within hair follicle stem cells for their survival.

Promote hair growth

"While more research is needed to improve our understanding of this pathway, our results suggest that therapeutics capable of decreasing levels of Wnt/β-catenin signaling in the skin could potentially be used to block growth of unwanted hair, and/or to treat certain skin tumors,” says  senior author Sarah Millar, PhD, professor in the departments of Dermatology and of Cell and Developmental Biology.

“Conversely, if delivered in a limited, safe and controlled way, agents that activate Wnt signaling might be used to promote hair growth in dormant hair follicles in conditions such as male pattern baldness.”

Function

The team examined the functions of Wnt proteins, which are small molecular messengers that convey information between cells and activate signaling via the intracellular molecule β-catenin.

By disrupting Wnt signaling in an animal model, the team found that hair growth was prevented, although stem cells were still maintained within the dormant hair follicles.

When the Dkk1 inhibitor they used was removed, the Wnt/β-catenin pathway resumed normal function, the stem cells were activated, and hair growth was restored.

Active

The team also unexpectedly found that the Wnt/β-catenin pathway is normally active in non-hairy regions, such as on the palms of hands, soles of feet and the tongue, as well as between hair follicles on the surface of the skin.

This finding is consistent with previous results showing that removing β-catenin prevents growth of skin tumors.

Looking ahead, the researchers aim to better understand the key components and functions of the Wnt/β-catenin pathway, with future work to include developing effective means of safely targeting therapeutics to the skin for clinical and cosmetic applications.

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